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Article

KLP-7 acts through the Ndc80 complex to limit pole number in C. elegans oocyte meiotic spindle assembly.

The Journal of cell biology - 14 Sept 2015

Connolly Amy A, Sugioka Kenji, Chuang Chien-Hui, Lowry Joshua B, Bowerman Bruce

Abstract excerpt

During oocyte meiotic cell division in many animals, bipolar spindles assemble in the absence of centrosomes, but the mechanisms that restrict pole assembly to a bipolar state are unknown. We show that KLP-7, the single mitotic centromere-associated kinesin (MCAK)/kinesin-13 in Caenorhabditis elegans, is required for bipolar oocyte meiotic spindle assembly. In klp-7(-) mutants, extra microtubules accumulated,...

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Identifiers

PMID: 26370499
DOI: 10.1083/jcb.201412010
PMCID: PMC4576866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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