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Article

Live imaging RNAi screen reveals genes essential for meiosis in mammalian oocytes.

Nature - 13 Aug 2015

Pfender Sybille, Kuznetsov Vitaliy, Pasternak Michał, Tischer Thomas, Santhanam Balaji, Schuh Melina

Abstract excerpt

During fertilization, an egg and a sperm fuse to form a new embryo. Eggs develop from oocytes in a process called meiosis. Meiosis in human oocytes is highly error-prone, and defective eggs are the leading cause of pregnancy loss and several genetic disorders such as Down's syndrome. Which genes safeguard accurate progression through meiosis is largely unclear. Here we develop high-content phenotypic screening...

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Identifiers

PMID: 26147080
DOI: 10.1038/nature14568
PMCID: PMC4538867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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