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Article

Autophagy modulates miRNA-mediated gene silencing and selectively degrades AIN-1/GW182 in C. elegans.

EMBO reports - 1 Jun 2013

Zhang Peipei, Zhang Hong

Abstract excerpt

MicroRNAs (miRNAs) post-transcriptionally repress gene expression via the miRNA-induced silencing complex (miRISC), which includes miRNA, Argonaute and a GW182 family member. Here we show that in Caenorhabditis elegans, miRNA-mediated gene silencing is modulated by macroautophagy, a lysosome-mediated degradation process. Loss of autophagy activity suppresses developmental defects caused by partially impaired...

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PMID: 23619095
DOI: 10.1038/embor.2013.53
PMCID: PMC3674441

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