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Article

Acute necrotizing encephalopathy-linked mutations in Nup358 impair interaction of Nup358 with TNRC6/GW182 and miRNA function.

Biochemical and biophysical research communications - 25 Jun 2021

Deshmukh Prachi, Singh Aditi, Khuperkar Deepak, Joseph Jomon

Abstract excerpt

MicroRNA (miRNA)-mediated translational suppression of mRNAs is involved in the regulation of multiple cellular processes. A recent study showed that Nup358, a protein mutated in a neurological disorder called acute necrotizing encephalopathy 1 (ANE1), helps in the coupling of miRNA-induced silencing complex (miRISC) - consisting of miRNA, AGO and GW182/TNRC6 proteins - with the target mRNA. Here we provide a...

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PMID: 33962210
DOI: 10.1016/j.bbrc.2021.04.027

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