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Article

Multivalent Recruitment of Human Argonaute by GW182.

Molecular cell - 17 Aug 2017

Elkayam Elad, Faehnle Christopher R, Morales Marjorie, Sun Jingchuan, Li Huilin, Joshua-Tor Leemor

Abstract excerpt

In miRNA-mediated gene silencing, the physical interaction between human Argonaute (hAgo) and GW182 (hGW182) is essential for facilitating the downstream silencing of the targeted mRNA. GW182 can interact with hAgo via three of the GW/WG repeats in its Argonaute-binding domain: motif-1, motif-2, and the hook motif. The structure of hAgo1 in complex with the hook motif of hGW182 reveals a "gate"-like interaction...

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Identifiers

PMID: 28781232
DOI: 10.1016/j.molcel.2017.07.007
PMCID: PMC5915679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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