Article
MicroRNA Expression: Protein Participants in MicroRNA Regulation.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
King Valeria M, Borchert Glen M
Abstract excerpt
MiRNAs are ~20 nt small RNAs that regulate networks of proteins using a seed region of nucleotides 2-8 to complement the 3' UTR of target mRNAs. The biogenesis and function of miRNAs as translational repressors is facilitated by protein counterparts that process primary and precursor miRNAs to maturity (Drosha/DCGR8 and Dicer/TRBP respectively) and incorporate miRNAs into the protein complex RISC to recognize and...
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