Article
Control of the localization and function of a miRNA silencing component TNRC6A by Argonaute protein.
Nucleic acids research - 16 Nov 2015
Nishi Kenji, Takahashi Tomoko, Suzawa Masataka, Miyakawa Takuya, Nagasawa Tatsuya, Ming Yvelt, Tanokura Masaru, Ui-Tei Kumiko
Abstract excerpt
GW182 family proteins play important roles in microRNA (miRNA)-mediated RNA silencing. They directly interact with Argonaute (Ago) proteins in processing bodies (P bodies), cytoplasmic foci involved in mRNA degradation and storage. Recently, we revealed that a human GW182 family protein, TNRC6A, is a nuclear-cytoplasmic shuttling protein, and its subcellular localization is regulated by its own nuclear...
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