Article
MicroRNA-binding is required for recruitment of human Argonaute 2 to stress granules and P-bodies.
Biochemical and biophysical research communications - 14 Oct 2011
Pare Justin M, López-Orozco Joaquín, Hobman Tom C
Abstract excerpt
Argonaute proteins are the core components of the RNA-induced silencing complex, the central effector of the mammalian RNA interference pathway. In the cytoplasm, they associate with at least two types of cytoplasmic RNA granules; processing bodies and stress granules, which function in mRNA degradation and translational repression, respectively. The significance of Argonaute association with these RNA granules...
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