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Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation.

Stem cells (Dayton, Ohio) - 1 Apr 2006

Miura Masako, Miura Yasuo, Padilla-Nash Hesed M, Molinolo Alfredo A, Fu Baojin, Patel Vyomesh, Seo Byoung-Moo, Sonoyama Wataru, Zheng Jenny J, Baker Carl C, Chen Wanjun, Ried Thomas, Shi Songtao

Abstract excerpt

Despite recent emerging evidence suggesting that cancer stem cells subsist in a variety of tumors, it is not yet fully elucidated whether postnatal stem cells are directly involved in tumorigenesis. We used murine bone marrow-derived mesenchymal stem cells (BMMSCs) as a model to test a hypothesis that tumorigenesis may originate from spontaneous mutation of stem cells. In this study, we demonstrated that murine...

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Identifiers

PMID: 16282438
DOI: 10.1634/stemcells.2005-0403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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