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Article

Genetically transforming human mesenchymal stem cells to sarcomas: changes in cellular phenotype and multilineage differentiation potential.

Cancer - 15 Oct 2009

Li Nan, Yang Rui, Zhang Wendong, Dorfman Howard, Rao Pulivarthi, Gorlick Richard

Abstract excerpt

BACKGROUND: The cell of origin of sarcoma is still unclear. High-grade osteosarcomas frequently demonstrate the potential for multipotent differentiation and, along with several other lines of evidence, suggest that human mesenchymal stem cells (hMSC) might be the cell of origin. METHODS: The hMSCs were transformed with retrovirus containing human telomerase reverse transcriptase (hTERT), simian virus 40 large t...

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Source

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Identifiers

PMID: 19593798
DOI: 10.1002/cncr.24519
PMCID: PMC2771660

Genes

MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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