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Article

Loss of interactions between p53 and survivin gene in mesenchymal stem cells after spontaneous transformation in vitro.

The international journal of biochemistry & cell biology - 1 Jun 2016

He Liu, Zhao Fangyu, Zheng Yong, Wan Yu, Song Jian

Abstract excerpt

Mesenchymal stem cells (MSC) from various animals undergo a spontaneous transformation in long-term culture. The transformed MSCs are highly tumorigenic and are likely to be the tumor-initiating cells of sarcoma. To explain why the transformed MSCs become tumorigenic, the present study investigated the characteristics of rat MSCs before and after spontaneous transformation. It was shown that although the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27046449
DOI: 10.1016/j.biocel.2016.03.018

Genes

MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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