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Detection of spontaneous tumorigenic transformation during culture expansion of human mesenchymal stromal cells

13 Nov 2013

Abstract excerpt

Human mesenchymal stem/stromal cells (MSCs) have been explored in a number of clinical trials as a possible method of treating various diseases. However, the effect of long-term cell expansion in vitro on physiological function and genetic stability is still poorly understood. In this study, MSC cultures derived from bone marrow and liver were evaluated for the presence of aberrant cells following long-term...

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PMID: 24227633
DOI: 10.1177/1535370213506802

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