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Article

Molecular Characterization of Spontaneous Mesenchymal Stem Cell Transformation

2 Jan 2008

Abstract excerpt

BACKGROUND: We previously reported the in vitro spontaneous transformation of human mesenchymal stem cells (MSC) generating a population with tumorigenic potential, that we termed transformed mesenchymal cells (TMC). METHODOLOGY/PRINCIPAL FINDINGS: Here we have characterized the molecular changes associated with TMC generation. Using microarrays techniques we identified a set of altered pathways and a greater...

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PMID: 18167557
DOI: 10.1371/journal.pone.0001398

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