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Article

A stem cell fusion model of carcinogenesis.

Journal of experimental therapeutics & oncology - 1 Jan 2005

He Xianghui, Tsang Tom C, Pipes Brain L, Ablin Richard J, Harris David T

Abstract excerpt

The origin of cancer remains enigmatic. Current models of carcinogenesis based on the gene mutation hypothesis have limitations in explaining many aspects of cancer. We put forward a new model of multistage carcinogenesis and propose that cancer development involves gene mutations and cell fusions. Specifically, cancer can result from a fusion between an "altered" pre-malignant cell and a bone marrow-derived stem...

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Identifiers

PMID: 16471036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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