Article
Tumorigenic potential is restored during differentiation in fusion-reprogrammed cancer cells.
Cell death & disease - 28 Jul 2016
Yao J, Zhang L, Hu L, Guo B, Hu X, Borjigin U, Wei Z, Chen Y, Lv M, Lau J T Y, Wang X, Li G, Hu Y-P
Abstract excerpt
Detailed understanding of the mechanistic steps underlying tumor initiation and malignant progression is critical for insights of potentially novel therapeutic modalities. Cellular reprogramming is an approach of particular interest because it can provide a means to reset the differentiation state of the cancer cells and to revert these cells to a state of non-malignancy. Here, we investigated the relationship...
Topics
- Adult
- Animals
- Carcinogenesis
- Cell Differentiation
- Cell Fusion
- Cell Line, Tumor
- Cellular Reprogramming
- Disease Progression
- Embryonic Stem Cells
- Humans
- Mice, Transgenic