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Article

Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation.

Cancer research - 1 Jul 2009

Røsland Gro Vatne, Svendsen Agnete, Torsvik Anja, Sobala Ewa, McCormack Emmet, Immervoll Heike, Mysliwietz Josef, Tonn Joerg-Christian, Goldbrunner Roland, Lønning Per Eystein, Bjerkvig Rolf, Schichor Christian

Abstract excerpt

Human mesenchymal stem cells (hMSC) aid in tissue maintenance and repair by differentiating into specialized cell types. Due to this ability, hMSC are currently being evaluated for cell-based therapies of tissue injury and degenerative diseases. However, extensive expansion ex vivo is a prerequisite to obtain the cell numbers required for human cell-based therapy protocols. Recent studies indicate that hMSC may...

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Identifiers

PMID: 19509230
DOI: 10.1158/0008-5472.CAN-08-4630

Genes

MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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