Article
Contribution of independent and pleiotropic genetic effects in the metabolic syndrome in a hypertensive rat.
PloS one - 1 Jan 2017
Ma Man Chun John, Pettus Janette M, Jakoubek Jessica A, Traxler Matthew G, Clark Karen C, Mennie Amanda K, Kwitek Anne E
Abstract excerpt
Hypertension is a major risk factor for cardiovascular disease, Type 2 diabetes, and end organ failure, and is often found concomitant with disorders characteristic of the Metabolic Syndrome (MetS), including obesity, dyslipidemia, and insulin resistance. While the associated features often occur together, the pathway(s) or mechanism(s) linking hypertension in MetS are not well understood. Previous work...
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