Article
LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain.
Cellular signalling - 1 Jun 2006
Korr Daniel, Toschi Luisella, Donner Peter, Pohlenz Hans-Dieter, Kreft Bertolt, Weiss Bertram
Abstract excerpt
Human leucine-rich repeat kinase 1 (LRRK1) is a multi-domain protein of unknown function belonging to the ROCO family of complex proteins. Here, we report the molecular characterization of human LRRK1 and show, for the first time, that LRRK1 is both a functional protein kinase and a GDP/GTP-binding protein. Binding of GTP to LRRK1 is specific, requires the GTPase-like Roc domain, and leads to a stimulation of...
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