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Article

The unconventional G-protein cycle of LRRK2 and Roco proteins.

Biochemical Society transactions - 15 Dec 2016

Terheyden Susanne, Nederveen-Schippers Laura M, Kortholt Arjan

Abstract excerpt

Mutations in the human leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of hereditary Parkinson's disease (PD). LRRK2 belongs to the Roco family of proteins, which are characterized by the presence of a Ras of complex proteins domain (Roc), a C-terminal of Roc domain (COR) and a kinase domain. Despite intensive research, much remains unknown about activity and the effect of PD-associated...

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Source

Identifiers

PMID: 27913669
DOI: 10.1042/BST20160224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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