Article
LRRK 2 gene mutations in the pathophysiology of the ROCO domain and therapeutic targets for Parkinson's disease: a review.
Journal of biomedical science - 14 Jun 2018
Chen Meng-Ling, Wu Ruey-Meei
Abstract excerpt
Parkinson's disease (PD) is the most common movement disorder and manifests as resting tremor, rigidity, bradykinesia, and postural instability. Pathologically, PD is characterized by selective loss of dopaminergic neurons in the substantia nigra and the formation of intracellular inclusions containing α-synuclein and ubiquitin called Lewy bodies. Consequently, a remarkable deficiency of dopamine in the striatum...
Topics
- Dopamine
- Dopaminergic Neurons
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mutation
- Parkinson Disease
- Protein Domains
- Substantia Nigra