Article
The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity.
Experimental cell research - 1 Oct 2007
Guo Luxuan, Gandhi Payal N, Wang Wen, Petersen Robert B, Wilson-Delfosse Amy L, Chen Shu G
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the leading cause of autosomal dominant Parkinson's disease (PD). LRRK2, a member of the ROCO protein family, contains both Ras GTPase-like (Roc) and kinase (MAPKKK) domains, as well as other functional motifs. Here, we have identified LRRK2 as the first mammalian ROCO protein that is an authentic and functional GTPase, defined by the ability to bind...
Topics
- Cell Line
- Enzyme Activation
- GTP Phosphohydrolases
- Guanosine Triphosphate
- Humans
- Hydrolysis
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Models, Biological
- Mutant Proteins
- Mutation