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Article

Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson’s Disease

1 Jan 2016

Abstract excerpt

Human LRRK2 (Leucine-Rich Repeat Kinase 2) has been associated with both familial and idiopathic Parkinson's disease (PD). Although several LRRK2 mediated pathways and interaction partners have been identified, the cellular functions of LRRK2 and LRRK2 mediated progression of PD are still only partially understood. LRRK2 belongs to the group of Roco proteins which are characterized by the presence of a Ras-like...

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PMID: 27293958
DOI: 10.1155/2016/7351985

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