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Caenorhabditis elegans models of tauopathy

15 Oct 2017

Abstract excerpt

ABSTRACT One of the hallmarks of the tauopathies, which include the neurodegenerative disorders, such as Alzheimer disease (AD), corticobasal degeneration, frontotemporal dementia, and progressive supranuclear palsy (PSP), is the abnormal accumulation of post‐translationally modified, insoluble tau. The result is a loss of neurons, decreased mental function, and complete dependence of patients on others....

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PMID: 29191965
DOI: 10.1096/fj.201701007

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