Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of Tau Phosphorylation Induces Neurotoxicity, Causing Developmental Defects and Degeneration in C. elegans.

Cells - 27 Apr 2026

Lu Man Pok, Rong Yi, Wang Jingyi, Yu Xiaochun, Liu Hongjiang, Wu Yingjie, Zhang Minxing, Chen Yining, Li Yidong, Yan Yuner, Liu Aiden, Li Zhaoyu

Abstract excerpt

Tau hyperphosphorylation is a hallmark of tauopathies and is closely associated with neurodegeneration. While targeting kinases and phosphatases to suppress tau phosphorylation has become an increasingly attractive therapeutic approach, the functional significance of tau phosphorylation and the potential risks of suppressing this process are not fully understood. Using C. elegans, we introduced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microtubules

Share to Mutation

Share to Nerve Degeneration

Share to Neurites

Share to Phosphorylation

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42121894
DOI: 10.3390/cells15090793
PMCID: PMC13163045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of Tau Phosphorylation Induces Neurotoxicity, Causing Developmental Defects and Degeneration in C. elegans.PMID 42121894Read ↗

Mimicking of tau hyperphosphorylation in GABAergic motoneurons of <i>C. elegans</i> induces severe peripheral and neuronal alterationsSemantic proximity Read ↗

Caenorhabditis elegans models of tauopathySemantic proximity Read ↗

Human tau compromises neuronal structural integrity in <i>C. elegans</i> promoted by age, stress and phosphorylationSemantic proximity Read ↗

A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tauSemantic proximity Read ↗

Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity.Semantic proximity Read ↗

Caenorhabditis elegans Models to Investigate the Mechanisms Underlying Tau Toxicity in TauopathiesSemantic proximity Read ↗

Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models.Semantic proximity Read ↗

Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic model.Semantic proximity Read ↗

Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy.Semantic proximity Read ↗

Phosphorylation Promotes Neurotoxicity in a<i>Caenorhabditis elegans</i>Model of TDP-43 ProteinopathySemantic proximity Read ↗

Dominant α-tubulin mutations rescue tauopathy neurodegenerative phenotypes in <i>C. elegans</i>Semantic proximity Read ↗

Alzheimer’s disease-relevant tau modifications selectively impact neurodegeneration and mitophagy in a novel <i>C. elegans</i> single-copy transgenic modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.