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Article

Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity.

Human molecular genetics - 15 Aug 2012

Fatouros Chronis, Pir Ghulam Jeelani, Biernat Jacek, Koushika Sandhya Padmanabhan, Mandelkow Eckhard, Mandelkow Eva-Maria, Schmidt Enrico, Baumeister Ralf

Abstract excerpt

Increased Tau protein amyloidogenicity has been causatively implicated in several neurodegenerative diseases, collectively called tauopathies. In pathological conditions, Tau becomes hyperphosphorylated and forms intracellular aggregates. The deletion of K280, which is a mutation that commonly appears in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17, enhances Tau aggregation...

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PMID: 22611162
DOI: 10.1093/hmg/dds190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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