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Article

Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy.

Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 2003

Kraemer Brian C, Zhang Bin, Leverenz James B, Thomas James H, Trojanowski John Q, Schellenberg Gerard D

Abstract excerpt

Frontotemporal dementia with parkinsonism chromosome 17 type (FTDP-17) is caused by mutations in MAPT, the gene encoding tau. FTDP-17 begins with executive function deficits and other abnormal behaviors, which progress to dementia. Neurodegenerative changes include accumulation of aggregated tau as neuronal and glial fibrillary tangles. Aggregated tau is seen in numerous other neurodegenerative diseases,...

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Identifiers

PMID: 12872001
DOI: 10.1073/pnas.1533448100
PMCID: PMC187908

Genes

MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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