Article
What makes a good genetic association study?
Lancet (London, England) - 8 Oct 2005
Hattersley Andrew T, McCarthy Mark I
Abstract excerpt
Genetic association studies are central to efforts to identify and characterise genomic variants underlying susceptibility to multifactorial disease. However, obtaining robust replication of initial association findings has proved difficult. Much of this inconsistency can be attributed to inadequacies in study design, implementation, and interpretation--inadequately powered sample groups are a major concern....
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