Article

Statistical Correction of the Winner’s Curse Explains Replication Variability in Quantitative Trait Genome-Wide Association Studies

2017-01-31

Abstract excerpt

Genome-wide association studies (GWAS) have identified hundreds of SNPs responsible for variation in human quantitative traits. However, genome-wide-significant associations often fail to replicate across independent cohorts, in apparent inconsistency with their apparent strong effects in discovery cohorts. This limited success of replication raises pervasive questions about the utility of the GWAS field. We ident...

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Literature Corpus work: 5c0ccbe5-28a5-534a-a3d1-8770d189ba77
DOI: 10.1101/104786

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