Article
How to use an article about genetic association: B: Are the results of the study valid?
JAMA - 14 Jan 2009
Attia John, Ioannidis John P A, Thakkinstian Ammarin, McEvoy Mark, Scott Rodney J, Minelli Cosetta, Thompson John, Infante-Rivard Claire, Guyatt Gordon
Abstract excerpt
In the first article of this series, we reviewed the basic genetics concepts necessary to understand genetic association studies. In this second article, we enumerate the major issues in judging the validity of these studies, framed as critical appraisal questions. Was the disease phenotype properly defined and accurately recorded by someone blind to the genetic information? Have any potential differences between...
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