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Article

Effectiveness of strategies to increase the validity of findings from association studies: size vs. replication.

BMC medical research methodology - 28 May 2010

Weitkunat Rolf, Kaelin Etienne, Vuillaume Grégory, Kallischnigg Gerd

Abstract excerpt

BACKGROUND: The capacity of multiple comparisons to produce false positive findings in genetic association studies is abundantly clear. To address this issue, the concept of false positive report probability (FPRP) measures "the probability of no true association between a genetic variant and disease given a statistically significant finding". This concept involves the notion of prior probability of an...

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Identifiers

PMID: 20509879
DOI: 10.1186/1471-2288-10-47
PMCID: PMC2896945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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