Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replication validity of genetic association studies.

Nature genetics - 1 Nov 2001

Ioannidis J P, Ntzani E E, Trikalinos T A, Contopoulos-Ioannidis D G

Abstract excerpt

The rapid growth of human genetics creates countless opportunities for studies of disease association. Given the number of potentially identifiable genetic markers and the multitude of clinical outcomes to which these may be linked, the testing and validation of statistical hypotheses in genetic epidemiology is a task of unprecedented scale. Meta-analysis provides a quantitative approach for combining the results...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Linkage
Share to Genetic Markers
Share to Bias

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Disease

Share to Meta-Analysis as Topic

Share to Odds Ratio

Share to Regression Analysis

Share to Reproducibility of Results

Source

Identifiers

PMID: 11600885
DOI: 10.1038/ng749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replication validity of genetic association studies.PMID 11600885Read ↗

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease.Semantic proximity Read ↗

Meta-analysis of genetic association studies.Semantic proximity Read ↗

Identifying systematic heterogeneity patterns in genetic association meta-analysis studies.Semantic proximity Read ↗

Meta-analysis of genetic association studies: methodologies, between-study heterogeneity and winner's curse.Semantic proximity Read ↗

Required sample size and nonreplicability thresholds for heterogeneous genetic associations.Semantic proximity Read ↗

Genetic diversity and disease susceptibility.Semantic proximity Read ↗

Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches.Semantic proximity Read ↗

On individual genome-wide association studies and their meta-analysis.Semantic proximity Read ↗

Meta-Analysis of Common and Rare Variants.Semantic proximity Read ↗

The Quality of Meta-Analyses of Genetic Association Studies: A Review With RecommendationsSemantic proximity Read ↗

Methods for meta-analysis of genetic data.Semantic proximity Read ↗

Methods for meta-analyses of genome-wide association studies: critical assessment of empirical evidence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.