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Article

Stimulation of mutagenesis by proportional deoxyribonucleoside triphosphate accumulation in Escherichia coli.

DNA repair - 8 Dec 2005

Wheeler Linda J, Rajagopal Indira, Mathews Christopher K

Abstract excerpt

Intracellular pool sizes of deoxyribonucleoside triphosphates (dNTPs) are highly regulated. Unbalanced dNTP pools, created by abnormal accumulation or deficiency of one nucleotide, are known to be mutagenic and to have other genotoxic consequences. Recent studies in our laboratory on DNA replication in vitro suggested that balanced accumulation of dNTPs, in which all four pools increase proportionately, also...

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Source

Identifiers

PMID: 16207537
DOI: 10.1016/j.dnarep.2005.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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