Repair system for noncanonical purines in Escherichia coli.

doi:10.1128/JB.185.10.3101-3110.2003

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Article

Repair system for noncanonical purines in Escherichia coli.

Journal of bacteriology - 1 May 2003

Burgis Nicholas E, Brucker Jason J, Cunningham Richard P

Abstract excerpt

Exposure of Escherichia coli strains deficient in molybdopterin biosynthesis (moa) to the purine base N-6-hydroxylaminopurine (HAP) is mutagenic and toxic. We show that moa mutants exposed to HAP also exhibit elevated mutagenesis, a hyperrecombination phenotype, and increased SOS induction. The E. coli rdgB gene encodes a protein homologous to a deoxyribonucleotide triphosphate pyrophosphatase from Methanococcus...

Topics

Adenine
Bacterial Proteins
Chromosome Breakage
Coenzymes
DNA
DNA Repair
DNA Replication
Deoxyribonuclease (Pyrimidine Dimer)
Endodeoxyribonucleases
Escherichia coli
Escherichia coli Proteins
Metalloproteins
Molybdenum Cofactors
Mutagenesis
Mutagens
Mutation
Pteridines
Purines

Source

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Identifiers

PMID: 12730170
DOI: 10.1128/JB.185.10.3101-3110.2003
PMCID: PMC154070

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