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Article

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools.

Nucleic acids research - 1 Mar 2011

Kumar Dinesh, Abdulovic Amy L, Viberg Jörgen, Nilsson Anna Karin, Kunkel Thomas A, Chabes Andrei

Abstract excerpt

The mechanisms by which imbalanced dNTPs induce mutations have been well characterized within a test tube, but not in vivo. We have examined mechanisms by which dNTP imbalances induce genome instability in strains of Saccharomyces cerevisiae with different amino acid substitutions in Rnr1, the large subunit of ribonucleotide reductase. These strains have different dNTP imbalances that correlate with elevated CAN1...

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Identifiers

PMID: 20961955
DOI: 10.1093/nar/gkq829
PMCID: PMC3045583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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