Article
Role of Ribonucleotide Reductase in Bacillus subtilis Stress-Associated Mutagenesis.
Journal of bacteriology - 15 Feb 2017
Castro-Cerritos Karla Viridiana, Yasbin Ronald E, Robleto Eduardo A, Pedraza-Reyes Mario
Abstract excerpt
The Gram-positive microorganism Bacillus subtilis relies on a single class Ib ribonucleotide reductase (RNR) to generate 2'-deoxyribonucleotides (dNDPs) for DNA replication and repair. In this work, we investigated the influence of RNR levels on B. subtilis stationary-phase-associated mutagenesis (SPM). Since RNR is essential in this bacterium, we engineered a conditional mutant of strain B. subtilis YB955...
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