Article
Elevated expression of DNA polymerase II increases spontaneous mutagenesis in Escherichia coli.
Mutation research - 1 Dec 2007
Al Mamun Abu Amar M
Abstract excerpt
Escherichia coli DNA polymerase II (Pol-II), encoded by the SOS-regulated polB gene, belongs to the highly conserved group B (alpha-like) family of "high-fidelity" DNA polymerases. Elevated expression of polB gene was recently shown to result in a significant elevation of translesion DNA synthesis at 3, N(4)-ethenocytosine lesion with concomitant increase in mutagenesis. Here, I show that elevated expression of...
Topics
- Base Sequence
- DNA Polymerase II
- DNA, Bacterial
- Drug Resistance, Bacterial
- Escherichia coli
- Escherichia coli Proteins
- Gene Expression
- Genes, Bacterial
- Mutagenesis
- Mutation
- Mutation, Missense
- Plasmids
- Rifampin