A reduction in ribonucleotide reductase activity slows down the chromosome replication fork but does not change its localization.

doi:10.1371/journal.pone.0007617

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Article

A reduction in ribonucleotide reductase activity slows down the chromosome replication fork but does not change its localization.

PloS one - 28 Oct 2009

Odsbu Ingvild, Morigen, Skarstad Kirsten

Abstract excerpt

BACKGROUND: It has been proposed that the enzymes of nucleotide biosynthesis may be compartmentalized or concentrated in a structure affecting the organization of newly replicated DNA. Here we have investigated the effect of changes in ribonucleotide reductase (RNR) activity on chromosome replication and organization of replication forks in Escherichia coli. METHODOLOGY/PRINCIPAL FINDINGS: Reduced concentrations...

Topics

Bacterial Outer Membrane Proteins
Blotting, Southern
Cell Cycle
Cell Division
Chromosomes
DNA
DNA Replication
DNA-Binding Proteins
Escherichia coli
Escherichia coli Proteins
Flow Cytometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydroxyurea

Models, Genetic

Mutation

Phenotype

Ribonucleotide Reductases

Ultraviolet Rays

Source

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Identifiers

PMID: 19898675
DOI: 10.1371/journal.pone.0007617
PMCID: PMC2773459

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