Article
Extreme dNTP pool changes and hypermutability in dcd ndk strains.
Mutation research - 1 Jan 2000
Tse Lawrence, Kang Tina Manzhu, Yuan Jessica, Mihora Danielle, Becket Elinne, Maslowska Katarzyna H, Schaaper Roel M, Miller Jeffrey H
Abstract excerpt
Cells lacking deoxycytidine deaminase (DCD) have been shown to have imbalances in the normal dNTP pools that lead to multiple phenotypes, including increased mutagenesis, increased sensitivity to oxidizing agents, and to a number of antibiotics. In particular, there is an increased dCTP pool, often accompanied by a decreased dTTP pool. In the work presented here, we show that double mutants of Escherichia coli...
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