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Article

Mutagenic cost of ribonucleotides in bacterial DNA.

Proceedings of the National Academy of Sciences of the United States of America - 31 Oct 2017

Schroeder Jeremy W, Randall Justin R, Hirst William G, O'Donnell Michael E, Simmons Lyle A

Abstract excerpt

Replicative DNA polymerases misincorporate ribonucleoside triphosphates (rNTPs) into DNA approximately once every 2,000 base pairs synthesized. Ribonucleotide excision repair (RER) removes ribonucleoside monophosphates (rNMPs) from genomic DNA, replacing the error with the appropriate deoxyribonucleoside triphosphate (dNTP). Ribonucleotides represent a major threat to genome integrity with the potential to cause...

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Share to Bacillus subtilis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29078353
DOI: 10.1073/pnas.1710995114
PMCID: PMC5676920

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