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Article

Cost of rNTP/dNTP pool imbalance at the replication fork.

Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 2013

Yao Nina Y, Schroeder Jeremy W, Yurieva Olga, Simmons Lyle A, O'Donnell Mike E

Abstract excerpt

The concentration of ribonucleoside triphosphates (rNTPs) in cells is far greater than the concentration of deoxyribonucleoside triphosphates (dNTPs), and this pool imbalance presents a challenge for DNA polymerases (Pols) to select their proper substrate. This report examines the effect of nucleotide pool imbalance on the rate and fidelity of the Escherichia coli replisome. We find that rNTPs decrease...

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Identifiers

PMID: 23882084
DOI: 10.1073/pnas.1309506110
PMCID: PMC3740908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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