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Article

Suppression of the E. coli SOS response by dNTP pool changes.

Nucleic acids research - 30 Apr 2015

Maslowska Katarzyna H, Makiela-Dzbenska Karolina, Fijalkowska Iwona J, Schaaper Roel M

Abstract excerpt

The Escherichia coli SOS system is a well-established model for the cellular response to DNA damage. Control of SOS depends largely on the RecA protein. When RecA is activated by single-stranded DNA in the presence of a nucleotide triphosphate cofactor, it mediates cleavage of the LexA repressor, leading to expression of the 30(+)-member SOS regulon. RecA activation generally requires the introduction of DNA...

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Identifiers

PMID: 25824947
DOI: 10.1093/nar/gkv217
PMCID: PMC4417155

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Source receipt: pubmed, retrieved 7 Sept 2026.

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