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Article

The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging.

Biochemical and biophysical research communications - 11 Nov 2005

Das Shankar Prasad, Sinha Pratima

Abstract excerpt

We show that the budding yeast protein Chl1p, required for sister-chromatid cohesion, also modulates transcriptional silencing at HMR and telomeres. The absence of this protein results in increased silencing at HMR and, conversely, in decreased silencing at the telomere. The regulation of silencing by Chl1p at these two loci is dependent on the presence of Sir proteins. Chl1p also acts synergistically with Sir2p...

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Share to Chromosomal Proteins, Non-Histone
Share to DNA, Ribosomal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Fungal

Share to Gene Silencing

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Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

Identifiers

PMID: 16182251
DOI: 10.1016/j.bbrc.2005.09.034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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