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Article

The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells.

Journal of cell science - 1 Dec 2006

Parish Joanna L, Rosa Jack, Wang Xiaoyu, Lahti Jill M, Doxsey Stephen J, Androphy Elliot J

Abstract excerpt

It has recently been suggested that the Saccharomyces cerevisiae protein Chl1p plays a role in cohesion establishment. Here, we show that the human ATP-dependent DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells. Localization studies show that ChlR1 diffusely coats mitotic chromatin in prophase and then translocates from the chromatids to concentrate at the spindle poles during the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17105772
DOI: 10.1242/jcs.03262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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