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Article

Rap1 in Candida albicans: an unusual structural organization and a critical function in suppressing telomere recombination.

Molecular and cellular biology - 1 Mar 2010

Yu Eun Young, Yen Wei-Feng, Steinberg-Neifach Olga, Lue Neal F

Abstract excerpt

Rap1 (repressor activator protein 1) is a conserved multifunctional protein initially identified as a transcriptional regulator of ribosomal protein genes in Saccharomyces cerevisiae but subsequently shown to play diverse functions at multiple chromosomal loci, including telomeres. The function of Rap1 appears to be evolutionarily plastic, especially in the budding yeast lineages. We report here our biochemical...

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Identifiers

PMID: 20008550
DOI: 10.1128/MCB.00986-09
PMCID: PMC2820896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rap1 in Candida albicans: an unusual structural organization and a critical function in suppressing telomere recombination.PMID 20008550Read ↗

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae.Semantic proximity Read ↗

A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.Semantic proximity Read ↗

Functional analysis of CaRAP1, encoding the Repressor/activator protein 1 of Candida albicans.Semantic proximity Read ↗

Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants.Semantic proximity Read ↗

Yeast Rap1 contributes to genomic integrity by activating DNA damage repair genes.Semantic proximity Read ↗

A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation.Semantic proximity Read ↗

Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length.Semantic proximity Read ↗

Mutational analysis defines a C-terminal tail domain of RAP1 essential for Telomeric silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Rif1: A Conserved Regulator of DNA Replication and Repair Hijacked by Telomeres in YeastsSemantic proximity Read ↗

Trypanosoma brucei RAP1 Has Essential Functional Domains That Are Required for Different Protein Interactions.Semantic proximity Read ↗

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenanceSemantic proximity Read ↗

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.Semantic proximity Read ↗

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