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Article

Elaboration, diversification and regulation of the Sir1 family of silencing proteins in Saccharomyces.

Genetics - 1 Apr 2009

Gallagher Jennifer E G, Babiarz Joshua E, Teytelman Leonid, Wolfe Kenneth H, Rine Jasper

Abstract excerpt

Heterochromatin renders domains of chromosomes transcriptionally silent and, due to clonal variation in its formation, can generate heritably distinct populations of genetically identical cells. Saccharomyces cerevisiae's Sir1 functions primarily in the establishment, but not the maintenance, of heterochromatic silencing at the HMR and HML loci. In several Saccharomyces species, we discovered multiple paralogs of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Sequence Homology, Amino Acid

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Source

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Identifiers

PMID: 19171939
DOI: 10.1534/genetics.108.099663
PMCID: PMC2666514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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