Article
Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.
Genes & development - 1 Oct 1994
Moretti P, Freeman K, Coodly L, Shore D
Abstract excerpt
The maintenance of transcriptional silencing at HM mating-type loci and telomeres in yeast requires the SIR2, SIR3, and SIR4 proteins, none of which appear to be DNA-binding proteins. Here we show that SIR3 and SIR4 interact with a carboxy-terminal domain of the silencer, telomere, and UAS-binding protein RAP1. We identified SIR3 and SIR4 in a two-hybrid screen for RAP1-interacting factors and showed that SIR3...
Topics
- Bacterial Proteins
- DNA, Fungal
- DNA-Binding Proteins
- Fungal Proteins
- Genes, Fungal
- Genes, Mating Type, Fungal
- Histone Deacetylases
- Mutation
- Protein Binding
- Repressor Proteins
- Saccharomyces cerevisiae