Article
Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.
Genes & development - 1 Oct 1994
Moretti P, Freeman K, Coodly L, Shore D
Abstract excerpt
The maintenance of transcriptional silencing at HM mating-type loci and telomeres in yeast requires the SIR2, SIR3, and SIR4 proteins, none of which appear to be DNA-binding proteins. Here we show that SIR3 and SIR4 interact with a carboxy-terminal domain of the silencer, telomere, and UAS-binding protein RAP1. We identified SIR3 and SIR4 in a two-hybrid screen for RAP1-interacting factors and showed that SIR3...
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