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Article

Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants.

Journal of molecular biology - 11 Jul 2008

Feeser Elizabeth A, Wolberger Cynthia

Abstract excerpt

The yeast Rap1 protein plays an important role in transcriptional silencing and in telomere length homeostasis. Rap1 mediates silencing at the HM loci and at telomeres by recruiting the Sir3 and Sir4 proteins to chromatin via a Rap1 C-terminal domain, which also recruits the telomere length regulators, Rif1 and Rif2. We report the 1.85 A resolution crystal structure of the Rap1 C-terminus, which adopts an...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18538788
DOI: 10.1016/j.jmb.2008.04.078
PMCID: PMC2516966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants.PMID 18538788Read ↗

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