Article
The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.
Genes & development - 1 Dec 1995
Brachmann C B, Sherman J M, Devine S E, Cameron E E, Pillus L, Boeke J D
Abstract excerpt
Genomic silencing is a fundamental mechanism of transcriptional regulation, yet little is known about conserved mechanisms of silencing. We report here the discovery of four Saccharomyces cerevisiae homologs of the SIR2 silencing gene (HSTs), as well as conservation of this gene family from bacte...
Topics
- Amino Acid Sequence
- Animals
- Cell Cycle
- Chromosomes, Fungal
- Conserved Sequence
- DNA-Binding Proteins
- Fibroblast Growth Factor 4
- Fibroblast Growth Factors
- Gene Dosage
- Gene Expression Regulation
- Genes, Fungal
- Histone Deacetylases
- Humans
- Molecular Sequence Data
- Mutation