Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p.

doi:10.1093/genetics/149.3.1205

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Article

Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p.

Genetics - 1 Jul 1998

Smith J S, Brachmann C B, Pillus L, Boeke J D

Abstract excerpt

Transcriptional silencing in Saccharomyces cerevisiae occurs at the silent mating-type loci HML and HMR, at telomeres, and at the ribosomal DNA (rDNA) locus RDN1. Silencing in the rDNA occurs by a novel mechanism that depends on a single Silent Information Regulator (SIR) gene, SIR2. SIR4, essent...

Topics

DNA, Ribosomal
DNA-Binding Proteins
Fungal Proteins
Gene Expression Regulation, Fungal
Genes, Fungal
Genes, Mating Type, Fungal
Genes, Regulator
Genotype
Histone Deacetylases
Models, Genetic
Phenotype
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Silent Information Regulator Proteins, Saccharomyces cerevisiae

Sirtuin 2

Sirtuins

Telomere

Trans-Activators

Transcription, Genetic

Source

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Identifiers

PMID: 9649515
DOI: 10.1093/genetics/149.3.1205
PMCID: PMC1460222

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9649515-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p.PMID 9649515Read ↗

Sif2p interacts with Sir4p amino-terminal domain and antagonizes telomeric silencing in yeast.Semantic proximity Read ↗

Locus specificity determinants in the multifunctional yeast silencing protein Sir2.Semantic proximity Read ↗

Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss.Semantic proximity Read ↗

A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors.Semantic proximity Read ↗

Spontaneous rDNA copy number variation modulates Sir2 levels and epigenetic gene silencing.Semantic proximity Read ↗

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.Semantic proximity Read ↗

SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR.Semantic proximity Read ↗

Bypassing the catalytic activity of SIR2 for SIR protein spreading in Saccharomyces cerevisiae.Semantic proximity Read ↗

The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging.Semantic proximity Read ↗

Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast.Semantic proximity Read ↗

HST1 increases replicative lifespan of a sir2Δ mutant in the absence of PDE2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

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