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Article

Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p.

Genetics - 1 Jul 1998

Smith J S, Brachmann C B, Pillus L, Boeke J D

Abstract excerpt

Transcriptional silencing in Saccharomyces cerevisiae occurs at the silent mating-type loci HML and HMR, at telomeres, and at the ribosomal DNA (rDNA) locus RDN1. Silencing in the rDNA occurs by a novel mechanism that depends on a single Silent Information Regulator (SIR) gene, SIR2. SIR4, essential for other silenced loci, paradoxically inhibits rDNA silencing. In this study, we elucidate a regulatory mechanism...

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Identifiers

PMID: 9649515
DOI: 10.1093/genetics/149.3.1205
PMCID: PMC1460222

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Related research

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Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p.PMID 9649515Read ↗

Sif2p interacts with Sir4p amino-terminal domain and antagonizes telomeric silencing in yeast.Semantic proximity Read ↗

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Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss.Semantic proximity Read ↗

A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors.Semantic proximity Read ↗

Spontaneous rDNA copy number variation modulates Sir2 levels and epigenetic gene silencing.Semantic proximity Read ↗

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.Semantic proximity Read ↗

SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR.Semantic proximity Read ↗

Bypassing the catalytic activity of SIR2 for SIR protein spreading in Saccharomyces cerevisiae.Semantic proximity Read ↗

The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging.Semantic proximity Read ↗

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