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Article

A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR.

Molecular cell - 1 Oct 2000

Dhillon N, Kamakaka R T

Abstract excerpt

Silencing at HMR requires silencers, and one of the roles of the silencer is to recruit Sir proteins. This work focuses on the function of Sir1p once it is recruited to the silencer. We have generated mutants of Sir1p that are recruited to the silencer but are unable to silence, and we have utilized these mutants to identify four proteins, Sir3p, Sir4p, Esc2p, and Htz1p, that when overexpressed, restored...

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Share to Chromatin
Share to Gene Silencing
Share to Genes, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Mating Factor

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Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

Identifiers

PMID: 11090616
DOI: 10.1016/s1097-2765(00)00076-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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