A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR.

doi:10.1016/s1097-2765(00)00076-9

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Article

A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR.

Molecular cell - 1 Oct 2000

Dhillon N, Kamakaka R T

Abstract excerpt

Silencing at HMR requires silencers, and one of the roles of the silencer is to recruit Sir proteins. This work focuses on the function of Sir1p once it is recruited to the silencer. We have generated mutants of Sir1p that are recruited to the silencer but are unable to silence, and we have utilized these mutants to identify four proteins, Sir3p, Sir4p, Esc2p, and Htz1p, that when overexpressed, restored...

Topics

Alleles
Chromatin
DNA-Binding Proteins
Fungal Proteins
Gene Silencing
Genes, Fungal
Histones
Mating Factor
Mutagenesis
Peptides
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Silent Information Regulator Proteins, Saccharomyces cerevisiae
Suppression, Genetic
Trans-Activators
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 11090616
DOI: 10.1016/s1097-2765(00)00076-9

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